Research

From the birth of a neuron to its integration into functional neuronal networks, signaling cascades mediated by kinases regulate all aspects of neuronal development.  Despite genomic evidence implicating kinases in neurological diseases, our understanding about how the human kinome controls neuronal development, how its dysfunction manifests in disease, and whether kinases can be targeted with specificity for therapeutic purposes is limited. The Yadav laboratory is interested in investigating the kinase signaling pathways that are important for neuronal development as well as in understanding how their dysfunction leads to neurodevelopmental and psychiatric disorders such as autism and schizophrenia.  Our lab utilizes a combination of powerful approaches in chemical-genetics, induced pluripotent stem cell (iPSC) technology, high-resolution live cell imaging and quantitative proteomics to investigate the role of kinases and their downstream targets in neuronal development and disease.

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